5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE

Base Information

• Chemical Name: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE
• CAS No.: 109544-39-0
• Molecular Formula: C11H9 Cl2 N O
• Molecular Weight: 242.1
• Hs Code.: 2934999090
• Mol file: 109544-39-0.mol

Synonyms:5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-OXAZOLE;5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE

Chemical Property of 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE

Chemical Property:

• Vapor Pressure: 3.37E-05mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 365.2°C at 760 mmHg
• Flash Point: 174.6°C
• PSA: 26.03000
• Density: 1.297g/cm³
• LogP: 4.04220

Purity/Quality:

98%min ^*data from raw suppliers

5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE

There total 4 articles about 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol (109544-10-7) → 2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole (109544-39-0)

Guidance literature:

With thionyl chloride; In toluene; at 0 ℃;

DOI:10.1055/s-2004-834862

Reference yield:

para-chlorobenzoic acid (74-11-3) → 2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole (109544-39-0)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 2 h / 50 °C

2: CH₃COONH₄; CH₃COOH / 24 h / Heating

3: SMEAH / tetrahydrofuran / 1 h / 0 °C

4: SOCl₂ / toluene / 0 °C

With thionyl chloride; ammonium acetate; potassium carbonate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1055/s-2004-834862

Reference yield:

ethyl 2-(4-chlorophenyl)-4-methyl-5-oxazolecarboxylate (109544-20-9) → 2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole (109544-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SMEAH / tetrahydrofuran / 1 h / 0 °C

2: SOCl₂ / toluene / 0 °C

With thionyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;

DOI:10.1055/s-2004-834862

upstream raw materials:

[2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol

para-chlorobenzoic acid

ethyl 2-(4-chlorophenyl)-4-methyl-5-oxazolecarboxylate

ethyl 2-(4-chlorobenzoyloxy)-3-oxo-butyrate

Downstream raw materials:

romazarit

Refernces