5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole

Base Information

Chemical Name:5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole
CAS No.:109544-39-0
Molecular Formula:C11H9 Cl2 N O
Molecular Weight:242.1
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10564204
Wikidata:Q82448818
Mol file:109544-39-0.mol

Synonyms:109544-39-0;5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole;5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-OXAZOLE;2-(4-chlorophenyl)-4-methyl-5-chloromethyloxazole;SCHEMBL9830911;DTXSID10564204;WYHZCQPFSIKTOX-UHFFFAOYSA-N;AKOS015962295;AC-16379

Suppliers and Price of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole 95+%
5g
$ 662.00

Chemenu
5-(chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole 95%
5g
$ 626.00

American Custom Chemicals Corporation
5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYLOXAZOLE 95.00%
5G
$ 1249.13

Total 8 raw suppliers

Chemical Property of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole

Chemical Property:

Vapor Pressure:3.37E-05mmHg at 25°C
Refractive Index:1.564
Boiling Point:365.2°C at 760 mmHg
Flash Point:174.6°C
PSA：26.03000
Density:1.297g/cm³
LogP:4.04220
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:241.0061193
Heavy Atom Count:15
Complexity:207

Purity/Quality:

98%min ^*data from raw suppliers

5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(OC(=N1)C2=CC=C(C=C2)Cl)CCl

Technology Process of 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole

There total 4 articles about 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109544-10-7
[2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol

: 109544-39-0
2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole

Guidance literature:: With thionyl chloride; In toluene; at 0 ℃;
DOI:10.1055/s-2004-834862

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 109544-39-0
2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 2 h / 50 °C

2: CH₃COONH₄; CH₃COOH / 24 h / Heating

3: SMEAH / tetrahydrofuran / 1 h / 0 °C

4: SOCl₂ / toluene / 0 °C

With thionyl chloride; ammonium acetate; potassium carbonate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2004-834862

Reference yield:

: 109544-20-9
ethyl 2-(4-chlorophenyl)-4-methyl-5-oxazolecarboxylate

: 109544-39-0
2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: SMEAH / tetrahydrofuran / 1 h / 0 °C

2: SOCl₂ / toluene / 0 °C

With thionyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;
DOI:10.1055/s-2004-834862