methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester

Base Information

• Chemical Name: methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester
• CAS No.: 606146-02-5
• Molecular Formula: C₁₁H₁₁NO₄S
• Molecular Weight: 253.279
• Mol file: 606146-02-5.mol

Synonyms:methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester

Chemical Property of methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester

There total 2 articles about methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanesulfonyl chloride (124-63-0) + 2-(3-hydroxy-1-propynyl)formanilide (606146-01-4) → methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester (606146-02-5)

Guidance literature:

With triethylamine; In dichloromethane; at -50 - 20 ℃;

DOI:10.1021/ol035143f

Reference yield:

N-formyl-2-iodoaniline (10113-39-0) → methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester (606146-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / CuI; DMF; Et₃N / Pd(PPh₃)2Cl₂ / 12 h / 20 °C

2: 75 percent / Et₃N / CH₂Cl₂ / -50 - 20 °C

With copper(l) iodide; triethylamine; N,N-dimethyl-formamide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane;

DOI:10.1021/ol035143f

Reference yield: 99.0%

dmap (1122-58-3) + methanesulfonic acid 3-(2-formylamino-phenyl)-prop-2-ynyl ester (606146-02-5) → 4-dimethylamino-1-[3-(2-formylamino-phenyl)-prop-2-ynyl]-pyridinium; methanesulfonate

Guidance literature:

In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol035143f

upstream raw materials:

methanesulfonyl chloride

2-(3-hydroxy-1-propynyl)formanilide

N-formyl-2-iodoaniline

Downstream raw materials:

2-(3-chloro-1-propynyl)formanilide

2-chloro-3-(chloropmethyl)quinoline