(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Base Information

Chemical Name:(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride
CAS No.:953077-37-7
Molecular Formula:C₁₄H₁₅F₅N₂O*ClH
Molecular Weight:358.739
Hs Code.:

Synonyms:(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Suppliers and Price of (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

There total 3 articles about (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (3S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,7-tetrahydro-1H-azepin-3-ammonium 3-carboxy-2,3-bis[(4-methylbenzoyl)oxy]propanoate di-p-toluoyl-L-tartrate

: 953077-37-7
(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Guidance literature:: (3S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,7-tetrahydro-1H-azepin-3-ammonium 3-carboxy-2,3-bis[(4-methylbenzoyl)oxy]propanoate di-p-toluoyl-L-tartrate; With hydrogenchloride; hydrogen; Pd-BaSO₄; In water; isopropyl alcohol; for 20h; under 4137.29 Torr;

With sodium hydroxide; In tert-butyl methyl ether; water;

With hydrogenchloride; 5-Nitrosalicylaldehyde; triethylamine; more than 3 stages;

Reference yield: 83.0%

: 1246403-34-8
N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

: 953077-37-7
(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Guidance literature:: With hydrogenchloride; water; In isopropyl alcohol; at 95 ℃; for 17h; under 1292.9 Torr; Inert atmosphere;
DOI:10.1021/jo101704b

Reference yield:

: 1258063-46-5
3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one hydrochloride

: 953077-37-7
(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Guidance literature:: 3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one hydrochloride; With 5-Nitrosalicylaldehyde; triethylamine; In water; isopropyl alcohol; at 50 ℃; for 22h;

With hydrogenchloride; In tert-butyl methyl ether; isopropyl alcohol; at 25 ℃;