N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

Base Information

Chemical Name:N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide
CAS No.:1246403-34-8
Molecular Formula:C₁₆H₁₇F₅N₂O₂
Molecular Weight:364.315
Hs Code.:

Synonyms:N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

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Chemical Property of N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

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Technology Process of N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

There total 2 articles about N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254841-10-5
N-((6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

: 1246403-34-8
N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

Guidance literature:: With sodium hydroxide; In water; dimethyl sulfoxide; at 20 - 60 ℃;
DOI:10.1021/jo101704b

Reference yield:

: 1254841-09-2
C₁₆H₁₉F₅N₂O₃

: N-((3S,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

: 1246403-34-8
N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

Guidance literature:: With dmap; pivaloyl chloride; triethylamine; at 35 - 40 ℃; for 1h;
DOI:10.1021/jo101704b

Reference yield: 83.0%

: 1246403-34-8
N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-azepan-3-yl)acetamide

: 953077-37-7
(3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)-azepan-2-one hydrochloride

Guidance literature:: With hydrogenchloride; water; In isopropyl alcohol; at 95 ℃; for 17h; under 1292.9 Torr; Inert atmosphere;
DOI:10.1021/jo101704b