1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

Base Information

Chemical Name:1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole
CAS No.:1072915-56-0
Molecular Formula:C₁₈H₁₃BrCl₂F₃N₅
Molecular Weight:507.14
Hs Code.:

Synonyms:1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

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Chemical Property of 1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

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Technology Process of 1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

There total 4 articles about 1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072915-86-6
2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]aniline

: 122-51-0
orthoformic acid triethyl ester

: 1072915-56-0
1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

Guidance literature:: With sodium azide; acetic acid; at 100 ℃; for 4h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1072915-56-0
1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Heating / reflux

2.2: 2 h / 60 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

4.1: hydrogenchloride; tin(ll) chloride / 1,4-dioxane; ethanol / 4 h / 90 °C

5.1: sodium azide; acetic acid / 4 h / 100 °C

With hydrogenchloride; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; acetic acid; trifluoroacetic acid; tin(ll) chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1025025-19-7
rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

: 1072915-56-0
1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

2: hydrogenchloride; tin(ll) chloride / 1,4-dioxane; ethanol / 4 h / 90 °C

3: sodium azide; acetic acid / 4 h / 100 °C

With hydrogenchloride; sodium azide; potassium carbonate; acetic acid; tin(ll) chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;