2-(4-TERT-BUTYLPHENYL)ACETALDEHYDE

Base Information

• Chemical Name: 2-(4-TERT-BUTYLPHENYL)ACETALDEHYDE
• CAS No.: 109347-45-7
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Hs Code.: 2912299000
• Mol file: 109347-45-7.mol

Synonyms:2-(4-tert-Butylphenyl)acetaldehyde;(p-tert-Butylphenyl)acetaldehyde;

Chemical Property of 2-(4-TERT-BUTYLPHENYL)ACETALDEHYDE

Chemical Property:

• Boiling Point: 257.8 °C at 760 mmHg
• Flash Point: 115.6 °C
• PSA: 17.07000
• Density: 0.946 g/cm³
• LogP: 2.72550

Purity/Quality:

99% ^*data from raw suppliers

(4-tert-Butylphenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-TERT-BUTYLPHENYL)ACETALDEHYDE

There total 12 articles about 2-(4-TERT-BUTYLPHENYL)ACETALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-tert-Butylstyrene (1746-23-2,26009-55-2) → 2-(4-(tert-butyl)phenyl)acetaldehyde (109347-45-7)

Guidance literature:

4-tert-Butylstyrene; With ammonium iodide; water; sodium dodecyl-sulfate; for 0.5h;

With Oxone; at 55 ℃; for 0.75h; regioselective reaction;

DOI:10.1002/adsc.201400986

Reference yield: 73.0%

4-tert-Butylphenylacetylene (772-38-3) → 2-(4-(tert-butyl)phenyl)acetaldehyde (109347-45-7)

Guidance literature:

With (2-(diphenylphosphino)-6-(2,4,6-triisopropylphenyl)pyridine); water; (η⁵-cyclopentadienyl) (η⁶-naphthalene)ruthenium hexafluorophosphate; In acetone; at 55 ℃; for 6h;

DOI:10.1021/ol062455k

Reference yield: 56.0%

2-(4-tert-butylphenyl)ethanol (5406-86-0) → 2-(4-(tert-butyl)phenyl)acetaldehyde (109347-45-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/acs.joc.9b01577

upstream raw materials:

4-tert-Butylstyrene

4-tert-Butylphenylacetylene

3-(4-tert-butylphenyl)propionaldehyde

lilial

Downstream raw materials:

3-(4-(tert-butyl)phenyl)quinoline

2-[2-(4-tert-Butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Refernces

• 1、 Byun, Woong Sub,Chung, Suk-Jae,Han, Young Taek,Jang, Kyungkuk,Jeong, Yoo-Seong,Lee, Jeeyeon,Lee, Sang Kook,Lee, Seungbeom,Park, Soo Kyung,Suh, Young-Ger. "A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction". . . Retrieved 2020.
• 2、 Wu, Rongpei,Gao, Ke. "B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of: In situ -formed enamines". supporting information. p. 4032 - 4036. Retrieved 2021/05/19.