5406-86-0

Basic information

• Product Name: 2-(4-tert-Butylphenyl)ethanol
• Synonyms: 4-TERT-BUTYLPHENETHYL ALCOHOL;p-(tert-butyl)-phenethylalcoho;p-tert-Butylphenetanol;P-TERT-BUTYL PHENETHYL ALCOHOL;4-tert-Butylphenethylalcohol,96%;2-(4-tert-Butylphenyl)ethanol
• CAS NO: 5406-86-0
• Molecular Formula: C₁₂H₁₈O
• Molecular Weight: 178.27
• EINECS: 410-020-5
• Product Categories: Aromatic alcohols and diols
• Mol File: 5406-86-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: 32-35°C
• Boiling Point: 141-143°C 15mm
• Flash Point: 141-143°C/15mm
• Appearance: /
• Density: 0,975 g/cm3
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.5209
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.93±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 2246595
• CAS DataBase Reference: 2-(4-tert-Butylphenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-Butylphenyl)ethanol(5406-86-0)
• EPA Substance Registry System: 2-(4-tert-Butylphenyl)ethanol(5406-86-0)

Safety Data

• Hazard Codes: Xn,N
• Statements: 41-48/22-51/53-62-52
• Safety Statements: 26-36/37/39-61
• RIDADR: 3077
• RTECS: SG7875000
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 5406-86-0(Hazardous Substances Data)

Usage

Uses

2-(4-tert-Butylphenyl)ethanol, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as an intermediate in organic synthesis.

InChI:InChI=1/C12H18O/c1-12(2,3)11-6-4-10(5-7-11)8-9-13/h4-7,13H,8-9H2,1-3H3

Upstream product

• 32857-63-9 4-t-butylphenylacetic acid 
• 1746-23-2 4-tert-Butylstyrene 
• 2783-28-0 4-tert-butylphenylethylene oxide 
• 1796-66-3 methyl (2-phenyl)ethyl carbonate 
• 60-12-8 2-phenylethanol 
• 7722-84-1 dihydrogen peroxide 
• 18127-01-0 3-(4-tert-butylphenyl)propionaldehyde 
• 943-27-1 4'-t-butylacetophenone 
• 14182-66-2 4-[(4-tert-butyl-phenyl)-thioacetyl]-morpholine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 19692-45-6 4-tert-butylbenzyl chloride 
• 3288-99-1 4-tert-butylbenzyl cyanide 
• 877-65-6 p-tert-butylbenzyl alcohol 

Downstream Products

• 503597-08-8 2-(4-tert-butylphenethyl)-1,3-propanediol 
• 503597-13-5 2,2-dimethyl-propionic acid 2-aminomethyl-4-(4-tert-butyl-phenyl)-butyl ester 
• 503597-10-2 4-(4-tert-butylphenyl)-2-(hydroxymethyl)butyl pivalate 
• 503597-06-6 diethyl 2-(4-tert-butylphenethyl)malonate 
• 503597-12-4 2-(azidomethyl)-4-(4-tert-butylphenyl)butyl pivalate 
• 503597-15-7 N-[4-(4-tert-butylphenyl)-2-(pivaloyloxymethyl)butyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 
• 120928-09-8 fenazaquin 
• 1044695-85-3 1-[4-(tert-butyl)phenyl]ethane-1,2-diol 

Relevant articles and documents

Design, synthesis, and evaluation of opioid analogues with non-peptidic β-turn scaffold: Enkephalin and endomorphin mimetics

We have identified a μ-selective opioid receptor agonist without a cationic amino group in the molecule from libraries of bicyclic β-turn peptidomimetics. The biologically active conformation of the lead is proposed to mimic an endomorphin type III 4 → 1

Method for preparing 4-tert-butylphenethyl alcohol

The invention discloses a method for preparing 4-tert-butylphenethyl alcohol. The method specifically comprises the following steps: reacting phenethyl alcohol with methyl chloroformate to generate methyl phenethyl carbonate; subjecting methyl phenylethyl

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins

Considering that stoichiometric borane and oxidant are required in the classical alkene anti-Markovnikov hydration process, it remains appealing to achieve the transformation in a catalytic protocol. Herein, a visible-light-mediated anti-Markovnikov addition of water to alkenes by using an organic photoredox catalyst in conjunction with a redox-active hydrogen atom donor was developed, which avoided the need for a transition-metal catalyst, stoichiometric borane, as well as oxidant. Both terminal and internal olefins are readily accommodated in this transformation to obtain corresponding primary and secondary alcohols in good yields with single regioselectivity. This procedure can be scaled up to gram scale with a 230 turnover number based on photocatalyst.