ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate

Base Information

• Chemical Name: ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate
• CAS No.: 1414859-60-1
• Molecular Formula: C₂₁H₁₈ClFO₃
• Molecular Weight: 372.824
• Mol file: 1414859-60-1.mol

Synonyms:ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate

Chemical Property of ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate

There total 2 articles about ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorophenyl)-3-buten-2-one (3160-40-5) + ethyl 2-fluoro-3-oxo-3-phenylpropionate (1479-22-7) → ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate (1414859-60-1)

Guidance literature:

With sodium ethanolate; caesium carbonate; In acetonitrile; at 90 ℃; for 1h; Microwave irradiation;

DOI:10.1039/c2gc36166c

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-ene-cyclohexanone-3-phenyl-5-(4′-chlorophenyl)-4-fluoro-4-carboxylate (1414859-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile / 0.67 h / 90 °C / Microwave irradiation

2: sodium ethanolate; caesium carbonate / acetonitrile / 1 h / 90 °C / Microwave irradiation

With sodium ethanolate; caesium carbonate; Selectfluor; In acetonitrile; 2: |Robinson Annulation;

DOI:10.1039/c2gc36166c

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

4-(4-chlorophenyl)-3-buten-2-one

ethyl 2-fluoro-3-oxo-3-phenylpropionate