1479-22-7Relevant articles and documents
FACILE SYNTHESIS OF α-FLUORO-β-KETOESTERS FROM POLYFLUOROALKENES
Ishikawa, Nobuo,Takaoka, Akio,Iwakiri, Hiroshi,Kubota, Satoshi,Kagaruki, S. R. F.
, p. 1107 - 1110 (1980)
Alkyl 2-chloro-1,2,2-trifluoroethyl ketones and aryl 1,2,2,2-tetrafluoroethyl ketones were respectively prepared by the Friedel-Crafts acylation of trifluoroethene and by the Grignard arylation of N,N-diethyl-1,2,2,2-tetrafluoropropionamide, a hydrolyzed product of hexafluoropropene-diethylamine adduct.These alkyl and aryl polyfluoroalkyl ketones were subjected to base-induced dehydrohalogenation, and resulting trifluorovinyl ketones were hydrolyzed in situ affording α-fluoro-β-ketoesters in good yields.
Selective fluorination of β-ketoesters using iodotoluene difluoride and a HF-amine complex
Hara, Shoji,Sekiguchi, Manabu,Ohmori, Akihiro,Fukuhara, Tsuyoshi,Yoneda, Norihiko
, p. 1899 - 1900 (1996)
β-Ketoesters are selectively fluorinated at the α-position by iodotoluene difluoride and a HF-pyridine complex.
A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones
Bi, Xihe,Sivaguru, Paramasivam,Song, Qingmin,Wang, Zikun,Zanoni, Giuseppe,Zhang, Xiaolong,Zhang, Xinyu
, (2021/12/23)
Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre
A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
García-Vázquez, Víctor,Hoteite, Larry,Lakeland, Christopher P.,Watson, David W.,Harrity, Joseph P. A.
supporting information, p. 2811 - 2815 (2021/05/05)
3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol.
FLUORINATED ORGANIC COMPOUND PRODUCTION METHOD
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Paragraph 0284; 0286, (2021/04/23)
An object of the present invention is to provide a method for producing a fluorinated organic compound, whereby an iodosylbenzene derivative can be easily separated and recovered. The above object can be achieved by a method for producing a fluorinated or