4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester
• CAS No.: 481006-41-1
• Molecular Formula: C₁₉H₁₇NO₂S
• Molecular Weight: 323.415
• Mol file: 481006-41-1.mol

Synonyms:4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property of 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester

There total 3 articles about 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (64276-62-6) + thiophenol (108-98-5) → 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester (481006-41-1) + 4-phenyl-2,5-bis-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:

With iodine; potassium iodide; In ethanol; for 5.5h; Heating;

Reference yield:

benzaldehyde (100-52-7) → 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester (481006-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃

2: sodium hydride / diethyl ether; various solvent(s) / 0.83 h / 20 °C

3: 60 percent / potassium iodide; iodine / ethanol / 5.5 h / Heating

With iodine; sodium hydride; potassium carbonate; potassium iodide; In diethyl ether; ethanol;

Reference yield:

ethyl cinnamate (4192-77-2) → 4-phenyl-5-phenylsulfanyl-1H-pyrrole-3-carboxylic acid ethyl ester (481006-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / diethyl ether; various solvent(s) / 0.83 h / 20 °C

2: 60 percent / potassium iodide; iodine / ethanol / 5.5 h / Heating

With iodine; sodium hydride; potassium iodide; In diethyl ether; ethanol;

upstream raw materials:

4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

thiophenol

benzaldehyde

ethyl cinnamate

Downstream raw materials:

4-phenyl-5-phenylsulfanyl-1-pyridin-4-ylmethyl-1H-pyrrole-3-carboxylic acid ethyl ester