64276-62-6

Usage

Uses

Used in Pharmaceutical Synthesis:
ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Fine Chemicals Production:
In the production of fine chemicals, ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE is utilized as a building block, enabling the creation of specialty compounds with specific applications in various industries.
Used in Anti-Inflammatory Research:
ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE is studied for its potential as an anti-inflammatory agent, indicating its use in research aimed at discovering new treatments for inflammatory conditions.
Used in Organic Synthesis Research:
As a versatile chemical compound, ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE is employed in research for the development of new organic synthesis methods, contributing to the advancement of chemical knowledge and innovation in organic chemistry.

InChI:InChI=1/C13H13NO2/c1-2-16-13(15)12-9-14-8-11(12)10-6-4-3-5-7-10/h3-9,14H,2H2,1H3

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 141-97-9 ethyl acetoacetate 
• 71333-60-3 (E)-1-Isocyano-2-phenyl-1-tosylethene 
• 5292-53-5 diethyl benzalmalonate 
• 4192-77-2 ethyl cinnamate 
• 79047-38-4 isocyanomethyl p-toluenesulfonate 
• 100-52-7 benzaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 
• 17282-40-5 N-(ethoxycarbonylmethyl)pyridinium bromide 

Downstream Products

• 131924-79-3 1-Benzyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-83-9 1-(2,4-Dichloro-benzyl)-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-81-7 1-(4-Chloro-benzyl)-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-82-8 1-(2-Chloro-benzyl)-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131924-80-6 1-(4-Fluoro-benzyl)-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 132040-12-1 4-phenyl-1H-pyrrole-3-carboxylic acid 
• 191668-11-8 1-allyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 483341-10-2 ethyl 1-oxiranylmethyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 481006-53-5 4-phenyl-5-phenylsulfanyl-1-pyridin-4-ylmethyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 483341-34-0 1-[3-(2-ethoxycarbonyl-phenylsulfanyl)-2-hydroxy-propyl]-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

Method of preparing 4,5-disubstituted 1,2,3-triazole with pyridinium salt

The invention relates to a method of synthesizing a 4,5-disubstituted 1,2,3-triazole compound. The method comprises the following step of by taking pyridine, halohydrocarbon, sulfonic ester, aldehydeand sodium azide as raw materials, and performing room-temperature reaction with a one-pot method. The synthetic method does not need a metal-containing catalyst, has the advantages of high yield of synthetic products, mild reaction condition, good functional group compatibility and the like, is simple in operation step, mild in reaction condition and wide in application range of a substrate, hasinnovativeness and a potential practical value and is suitable for industrial production.

Palladium(II) Catalyzed C-H Functionalization Cascades for the Diastereoselective Synthesis of Polyheterocycles

C-H activation offers huge potential in the generation of complex structures from simple starting materials. Herein we report the development of a highly diastereoselective palladium(II) catalyzed C-H functionalization cascade to produce novel, unsaturate

Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles

A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial ac

Solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates: Application to the total synthesis of (±)-rhazinilam

A solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates via a Pd(OAc)2 catalyzed oxidative Heck reaction was first realized. The corresponding C2 and C5 alkenylation products were obtained in good yields with high regioselectivities, respectively. The selective C5-alkenylation was successfully applied to the total synthesis of (±)-rhazinilam.

NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.

Arylthiopyridylmethylisopropylpyrrole carbinols, novel NNRTIs endowed with potent anti-HIV-1 activity

Pyrrole analogues of the NNRTI S-1153 were synthesized and tested as anti-HIV-1 agents. Among test compounds 5-(3,5-dichlorophenylthio)-4-isopropyl-1-(4-pyridylmethyl)-1H-pyrrole-3- methanol was the most active in cell-based assays against HIV-1 wt and K1

Flash vacuum pyrolysis of N-alkenylbenzotriazoles and N-alkenylisoxazolones

The flash vacuum pyrolysis of 1-(2-ethoxycarbonylethenyl)benzotriazole has been reinvestigated, and the processes leading to the formation of ethyl indole-3-carboxylate and 2-ethoxyquinolin-4(1H)-one elucidated. Similar pathways are followed in the flash vacuum pyrolysis of the corresponding benzisoxazolone. Some N-ethenylisoxazolones have been pyrolysed to form pyrroles, but rearrangement of the intermediate carbenes may be observed. Photolysis of the isoxazolones gives carbenes that may be captured by solvent or give pyrroles. CSIRO 2000.