(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

Base Information

Chemical Name:(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester
CAS No.:872311-80-3
Molecular Formula:C₂₉H₄₂N₄O₆
Molecular Weight:542.676
Hs Code.:

(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

Synonyms:(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

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Chemical Property of (2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

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Technology Process of (2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

There total 10 articles about (2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 802911-18-8
(2S,3S)-2-Amino-3-methyl-pentanoic acid dicyclopropylmethyl ester

: 872311-80-3
(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.50 g / TMP / CH₂Cl₂ / 6 h / 20 °C

2.1: H₂ / Pd/C / ethyl acetate / 2 h / ambient pressure

3.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

3.2: 405 mg / TMP / CH₂Cl₂ / 15 h / 20 °C

4.1: H₂; Et₂NH / Pd/C / acetonitrile / 0.5 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1002/chem.200400249

Reference yield:

: 321524-72-5
N-Z-3-(2S,3R)-β-methylphenylalanine

: 872311-80-3
(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.50 g / TMP / CH₂Cl₂ / 6 h / 20 °C

2.1: H₂ / Pd/C / ethyl acetate / 2 h / ambient pressure

3.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

3.2: 405 mg / TMP / CH₂Cl₂ / 15 h / 20 °C

4.1: H₂; Et₂NH / Pd/C / acetonitrile / 0.5 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1002/chem.200400249

Reference yield:

: 802911-34-8
(2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester

: 872311-80-3
(2S,3S)-2-{(2S,3R)-2-[(R)-2-Amino-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid dicyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 405 mg / TMP / CH₂Cl₂ / 15 h / 20 °C

2.1: H₂; Et₂NH / Pd/C / acetonitrile / 0.5 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200400249