802911-34-8

Basic information

• Product Name: (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester
• Synonyms: (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester
• CAS NO: 802911-34-8
• Molecular Weight: 386.535
• Mol File: 802911-34-8.mol

Chemical Properties

• CAS DataBase Reference: (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester(802911-34-8)
• EPA Substance Registry System: (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester(802911-34-8)

Safety Data

• Hazardous Substances Data: 802911-34-8(Hazardous Substances Data)

Upstream product

• 25488-27-1 threo-L-(2S,3R)-β-methylphenylalanine 
• 14300-33-5 dicyclopropylmethanol 
• 71989-23-6 Fmoc-Ile-OH 
• 59850-51-0 threo-(+)-(2S,3R)-L-β-Methylphenylalanine hydrochloride 
• 103321-51-3 ((1S,2S)-1-Chlorocarbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 173254-32-5 N-Fmoc-isoleucine dicyclopropylmethyl ester 
• 321524-72-5 N-Z-3-(2S,3R)-β-methylphenylalanine 
• 802911-18-8 (2S,3S)-2-Amino-3-methyl-pentanoic acid dicyclopropylmethyl ester 
• 802911-33-7 (2S,3S)-2-((2S,3R)-2-Benzyloxycarbonylamino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester 

Relevant articles and documents

(2R,1'S,2'R)- And (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines and their incorporation into hormaomycin analogues

Efficient and scalable syntheses of enantiomerically pure (2 R ,1' S ,2' R )- and (2 S ,1' S ,2' R )-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines 9a - c , as well as allo-D-threonine ( 4 ) and ( 2 S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S )- and (R )-2-[( N-benzylprolyl)amino]benzophenone [(S)- and (R)-10 ] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin ( 1 ) with (fluoromethylcyclopropyl) alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity.

First total synthesis of hormaomycin, a naturally occurring depsipeptide with interesting biological activities

Some unique features were disclosed during the structure elucidation of the cyclic depsipeptide hormaomycin (1), first isolated in 1989 from a Streptomyces griseoflavus strain and found to have quite an interesting spectrum of biological activities. Besid