N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide

Base Information

• Chemical Name: N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide
• CAS No.: 701953-79-9
• Molecular Formula: C₁₅H₁₄N₄O₄S₂
• Molecular Weight: 378.433

Synonyms:N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide

Chemical Property of N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide

There total 4 articles about N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxy-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide (89320-02-5) + 1H-1,2,4-triazole-5-thiol (3179-31-5) → N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide (701953-79-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2013.07.056

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide (701953-79-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 5 h / 20 °C / Cooling with ice

2: SiO₂-supported NaIO₄ / dichloromethane / 2 h / 20 °C

3: N,N-dimethyl-formamide / 4 h / 20 °C

With SiO₂-supported NaIO₄; In pyridine; dichloromethane; N,N-dimethyl-formamide; 3: |Michael Addition;

DOI:10.1016/j.ejmech.2013.07.056

Reference yield:

N-(4-hydroxyphenyl)-4-methoxybenzenesulfonamide → N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-methoxybenzenesulfonamide (701953-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SiO₂-supported NaIO₄ / dichloromethane / 2 h / 20 °C

2: N,N-dimethyl-formamide / 4 h / 20 °C

With SiO₂-supported NaIO₄; In dichloromethane; N,N-dimethyl-formamide; 2: |Michael Addition;

DOI:10.1016/j.ejmech.2013.07.056

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

4-methoxy-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide

1H-1,2,4-triazole-5-thiol

p-aminophenol hydrochloride

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