N-benzoyl-2-pyrrolidinecarbaldehyde

Base Information

• Chemical Name: N-benzoyl-2-pyrrolidinecarbaldehyde
• CAS No.: 72351-43-0
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• Mol file: 72351-43-0.mol

Synonyms:N-benzoyl-2-pyrrolidinecarbaldehyde

Chemical Property of N-benzoyl-2-pyrrolidinecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzoyl-2-pyrrolidinecarbaldehyde

There total 5 articles about N-benzoyl-2-pyrrolidinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone (72351-42-9) → N-benzoyl-2-pyrrolidinecarbaldehyde (72351-43-0)

Guidance literature:

With hydrogenchloride; sodium bromate; N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-benzoylamide; In dichloromethane; water; at 20 ℃; for 4h;

DOI:10.1002/cjoc.201400141

Reference yield: 85.0%

1-benzoyl-pyrrolidine-2-carbaldehyde O-benzyl-oxime (359876-41-8) → N-benzoyl-2-pyrrolidinecarbaldehyde (72351-43-0)

Guidance literature:

With hydrogenchloride; formaldehyd; at 20 ℃; for 3h;

Reference yield: 54.0%

1-benzoyl-2,5-dihydropyrrole (15431-85-3) + carbon monoxide (201230-82-2) → n-benzoylpyrrolidine (3389-54-6) + N-benzoyl-2-pyrrolidinecarbaldehyde (72351-43-0) + N-benzoylproline (195719-48-3)

Guidance literature:

With hydrogen; dicobalt octacarbonyl; In tetrahydrofuran; water; at 110 ℃; for 24h; under 91200.1 Torr; Product distribution; Mechanism; analogous reaction of N-benzoyl-2-pyrroline (100 deg C, 2h); addition of PdCl₂(PPh₃)2 or CH₃CONH₂;

DOI:10.1246/bcsj.64.620

upstream raw materials:

1-benzoyl-2,5-dihydropyrrole

carbon monoxide

(2,3-dihydro-1H-pyrrol-1-yl)(phenyl)methanone

1-benzoyl-pyrrolidine-2-carbaldehyde O-benzyl-oxime

Downstream raw materials:

N-benzoyl-(2R)-methoxycarbonylpyrrolidine

N-benzoyl-L-proline methyl ester