benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate

Base Information

• Chemical Name: benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate
• CAS No.: 56414-68-7
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 56414-68-7.mol

Synonyms:benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate

Chemical Property of benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate

There total 2 articles about benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + 1-(prop-2-ene-1-sulfinyl)pyrrolidine (1532548-78-9) → benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate (56414-68-7)

Guidance literature:

With dmap; In chloroform; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol403508

Reference yield:

pyrrolidine (123-75-1) + (S)-N-(benzyloxycarbonyl)valine (1149-26-4) → benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate (56414-68-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 20 deg C, 18 h;

DOI:10.1021/jm00115a001

Reference yield: 67.0%

benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate (56414-68-7) → 1-<(2S)-3-methyl-2-(methylamino)butyl>pyrrolidine (156004-66-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm00115a001

upstream raw materials:

pyrrolidine

(S)-N-(benzyloxycarbonyl)valine

1-(prop-2-ene-1-sulfinyl)pyrrolidine

Downstream raw materials:

1-<(2S)-3-methyl-2-(methylamino)butyl>pyrrolidine

ICI 197067

N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-3-phenyl-propionamide

N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-phenyl-acetamide