3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Base Information

Chemical Name:3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid
CAS No.:1428526-53-7
Molecular Formula:C₂₄H₂₁N₄O₆P
Molecular Weight:492.428
Hs Code.:

Synonyms:3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Suppliers and Price of 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

There total 14 articles about 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1428526-52-6
diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate

: 1428526-53-7
3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 48h;

Reference yield:

: 960388-60-7
(3-bromophenyl)(4-methoxyphenyl)methylamine

: 1428526-53-7
3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 0 °C

5: trimethylsilyl bromide / dichloromethane / 48 h / 0 - 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trimethylsilyl bromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 100-66-3
methoxybenzene

: 1428526-53-7
3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: aluminum (III) chloride / dichloromethane / 20 °C / Inert atmosphere

2: 24 h / 185 °C

3: potassium hydroxide / methanol / 24 h / 185 °C

4: triethylamine / dichloromethane / 0 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

6: hydrogenchloride / 1,4-dioxane / 20 °C

7: triethylamine / dichloromethane / 0 °C

8: trimethylsilyl bromide / dichloromethane / 48 h / 0 - 20 °C

With hydrogenchloride; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trimethylsilyl bromide; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;