diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate

Base Information

• Chemical Name: diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate
• CAS No.: 1428526-52-6
• Molecular Formula: C₂₈H₂₉N₄O₆P
• Molecular Weight: 548.535
• Mol file: 1428526-52-6.mol

Synonyms:diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate

Chemical Property of diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate

There total 13 articles about diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

diethyl 3-(amino(4-methoxyphenyl)methyl)phenylphosphonate hydrochloride + 4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid (56406-45-2) → diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate (1428526-52-6)

Guidance literature:

4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid; With thionyl chloride; at 20 ℃; for 3h;

diethyl 3-(amino(4-methoxyphenyl)methyl)phenylphosphonate hydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

C10H6ClN3O2 + diethyl 3-(amino(4-methoxyphenyl)methyl)phenylphosphonate hydrochloride → diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate (1428526-52-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

(3-bromophenyl)(4-methoxyphenyl)methylamine (960388-60-7) → diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate (1428526-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

upstream raw materials:

methoxybenzene

(3-bromophenyl)(4-methoxyphenyl)methylamine

C₁₅H₁₄BrNO₂

C₁₉H₂₂BrNO₃

Downstream raw materials:

3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid