(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

Base Information

Chemical Name:(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide
CAS No.:124415-93-6
Molecular Formula:C₁₆H₁₈N₂O₂S
Molecular Weight:302.397
Hs Code.:

Synonyms:(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

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Technology Process of (+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

There total 6 articles about (+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 146645-51-4,146645-52-5,124415-67-4
(+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine

: 109-94-4
formic acid ethyl ester

: 124415-92-5
(+/-)-2-amino-N-formyl-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine

: 124415-93-6
(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

Guidance literature:: for 8h; Heating;
DOI:10.1021/jm00045a004

Reference yield:

: 61495-04-3
2,2-dimethyl-N-(2-methylphenyl)propanamide

: 124415-93-6
(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) hexane, THF, 2-10 deg C, 1 h, 2.) hexane, THF, 0-10 deg C, 1 h

2: 6 N HCl / 24 h / 100 °C

3: 1.) dicyclohexylcarbodiimide, 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, 0 deg C, 2 h

With pyridine; hydrogenchloride; n-butyllithium; dicyclohexyl-carbodiimide;
DOI:10.1021/jm00045a004

Reference yield:

: 3-methyl-2-thiophenecarboxaldehyde methylimine

: 124415-93-6
(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) hexane, THF, 2-10 deg C, 1 h, 2.) hexane, THF, 0-10 deg C, 1 h

2: 6 N HCl / 24 h / 100 °C

3: 1.) dicyclohexylcarbodiimide, 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, 0 deg C, 2 h

With pyridine; hydrogenchloride; n-butyllithium; dicyclohexyl-carbodiimide;
DOI:10.1021/jm00045a004