thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

Base Information

Chemical Name:thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone
CAS No.:1352874-91-9
Molecular Formula:C₁₈H₁₉F₃N₂O₃S
Molecular Weight:400.422
Hs Code.:

Synonyms:thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

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Chemical Property of thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

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Technology Process of thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

There total 4 articles about thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 1186134-34-8
C₁₃H₁₇F₃N₂O₂

: 1352874-91-9
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 8h; Cooling with ice;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1352874-91-9
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / Reflux

2: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane; chloroform;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 102793-81-7
1-(2-bromoethoxy)-4-(trifluoromethoxy)benzene

: 1352874-91-9
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

2: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

With hydrogen bromide; triethylamine; In ethanol; chloroform; water;
DOI:10.1016/j.ejmech.2014.03.075