thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

Base Information

Chemical Name:thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride
CAS No.:1352792-19-8
Molecular Formula:C₁₈H₁₉F₃N₂O₃S*ClH
Molecular Weight:436.883
Hs Code.:

Synonyms:thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

Chemical Property:

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Technology Process of thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

There total 5 articles about thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352874-91-9
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone

: 1352792-19-8
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1352792-19-8
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 4 h / Reflux

2: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethanol

With hydrogenchloride; thionyl chloride; triethylamine; In ethanol; dichloromethane; chloroform;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 102793-81-7
1-(2-bromoethoxy)-4-(trifluoromethoxy)benzene

: 1352792-19-8
thiophen-2-yl(4-(2-(4-(trifluoromethoxy)phenoxy)ethyl)piperazin-1-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

2: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethanol

With hydrogenchloride; hydrogen bromide; triethylamine; In ethanol; chloroform; water;
DOI:10.1016/j.ejmech.2014.03.075