2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile
CAS No.:1349830-64-3
Molecular Formula:C₁₉H₁₈N₄O₃
Molecular Weight:350.377
Hs Code.:

Synonyms:2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

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Chemical Property of 2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

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Technology Process of 2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

There total 4 articles about 2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 773837-37-9
sodium cyanide

: 1349830-68-7
((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

: 1349830-64-3
2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 4h;

Reference yield:

: 1349830-66-5
6-((2S,5R)-2-(hydroxymethyl)-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

: 1349830-64-3
2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 4 h / 120 °C

With triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 337463-88-4
6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

: 1349830-64-3
2-((2R,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]-oxazin-6-yl)-5-phenylmorpholin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium tert-butoxide / tert-Amyl alcohol; N,N,N,N,N,N-hexamethylphosphoric triamide / 60 °C / Inert atmosphere

2: triethylamine / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 4 h / 120 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; triethylamine; lithium tert-butoxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; tert-Amyl alcohol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b01515