((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

Base Information

Chemical Name:((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate
CAS No.:1349830-68-7
Molecular Formula:C₁₉H₂₁N₃O₆S
Molecular Weight:419.458
Hs Code.:

Synonyms:((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

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Chemical Property of ((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

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Technology Process of ((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

There total 3 articles about ((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1349830-66-5
6-((2S,5R)-2-(hydroxymethyl)-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

: 7143-01-3
Methanesulfonic anhydride

: 1349830-68-7
((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 8h;

Reference yield:

: 337463-88-4
6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

: 1349830-68-7
((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium tert-butoxide / tert-Amyl alcohol; N,N,N,N,N,N-hexamethylphosphoric triamide / 60 °C / Inert atmosphere

2: triethylamine / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; triethylamine; lithium tert-butoxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; tert-Amyl alcohol; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.7b01515

Reference yield:

: 1349829-37-3
((2S,5R)-5-phenylmorpholin-2-yl)methanol

: 1349830-68-7
((2S,5R)-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium tert-butoxide / tert-Amyl alcohol; N,N,N,N,N,N-hexamethylphosphoric triamide / 60 °C / Inert atmosphere

2: triethylamine / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5-(diisopropylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole; triethylamine; lithium tert-butoxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; tert-Amyl alcohol; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.7b01515