methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

Base Information

• Chemical Name: methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate
• CAS No.: 1055051-35-8
• Molecular Formula: C₁₂H₁₀F₃NO₃
• Molecular Weight: 273.212
• Mol file: 1055051-35-8.mol

Synonyms:methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

Chemical Property of methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

There total 5 articles about methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-hydroxy-2-{[4-(trifluoromethyl)phenyl]carbonylamino}propanoate + diisopropyl (E)-azodicarboxylate (2446-83-5) → methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate (1055051-35-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran;

Reference yield:

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) + 4-(trifluoromethyl)benzenimidic acid ethyl ester hydrochloride (15816-25-8) → methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate (1055051-35-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c2cc00081d

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate (1055051-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / Reflux

2: acetic anhydride / Reflux

3: hydrogenchloride / 0 - 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; acetic anhydride; sodium carbonate; triethylamine; In methanol; dichloromethane; water;

DOI:10.1039/c2cc00081d

upstream raw materials:

diisopropyl (E)-azodicarboxylate

4-Trifluoromethylbenzaldehyde

4-CF₃C₆H₄CN

4-(trifluoromethyl)benzaldehyde oxime