7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
CAS No.:1315513-78-0
Molecular Formula:C₂₇H₂₉N₇O₃
Molecular Weight:499.572
Hs Code.:

Synonyms:7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of 7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Technology Process of 7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

There total 7 articles about 7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1124330-14-8
2-methoxy-4-(1-methylpiperidin-4-yl)aniline

: 1315513-48-4
7-amino-2-methanesulfinyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

: 1315513-47-3
7-amino-2-methanesulfonyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

: 1315513-78-0
7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 6h;

Reference yield:

: 106475-47-2
2-methanesulfanyl-4-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

: 1315513-78-0
7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / ethanol / 20 °C

2.1: triethylamine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

3.2: 20 °C / Cooling with ice

3.3: 5 h / 20 °C / Cooling with ice

4.1: butan-1-ol / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h

6.1: 1-methyl-pyrrolidin-2-one / 6 h / 110 °C

With trifluoro-[1,3,5]triazine; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

Reference yield:

: 62-53-3
aniline

: 1315513-78-0
7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

2.1: sodium hydroxide; water / ethanol / 20 °C

3.1: triethylamine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

4.2: 20 °C / Cooling with ice

4.3: 5 h / 20 °C / Cooling with ice

5.1: butan-1-ol / Reflux

6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h

7.1: 1-methyl-pyrrolidin-2-one / 6 h / 110 °C

With trifluoro-[1,3,5]triazine; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil; butan-1-ol;