Technology Process of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-4-fluoro-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine
There total 2 articles about 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-4-fluoro-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-fluoro-4-phenylpiperidine hydrochloride; 3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbaldehyde;
In
1,2-dichloro-ethane;
at 20 ℃;
With
acetic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
for 4h;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate / water; 1,4-dioxane / 0.22 h / 150 °C / Microwave irradiation
2.1: osmium(VIII) oxide; sodium periodate / tert-butyl alcohol; water; 1,4-dioxane / 2 h / 20 °C
3.1: 1,2-dichloro-ethane / 20 °C
3.2: 4 h / 20 °C
3.3: 20 °C
With
sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate;
In
1,4-dioxane; water; 1,2-dichloro-ethane; tert-butyl alcohol;
1.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00913