6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

Base Information

Chemical Name:6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine
CAS No.:1361570-34-4
Molecular Formula:C₁₈H₁₂F₂N₆O₂
Molecular Weight:382.329
Hs Code.:

Synonyms:6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

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Chemical Property of 6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

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Technology Process of 6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

There total 5 articles about 6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361570-33-3
6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridine

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1361570-34-4
6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

Guidance literature:: 6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2-amino-6-chloro-3-nitropyridine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 1361570-32-2
1-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)ethanone

: 1361570-34-4
6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With pyridine; dmap; sodium hydride; hydrazine hydrate; In pyridine; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 745784-04-7
3,5-difluoropyridine-2-carboxylic acid

: 1361570-34-4
6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: sodium chloride / dimethyl sulfoxide; water / 0.5 h / 150 °C / Microwave irradiation

4.1: pyridine; hydrazine hydrate; dmap / pyridine / 0.5 h / Reflux

5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 1 h / 20 °C

With pyridine; dmap; thionyl chloride; sodium hydride; hydrazine hydrate; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;