745784-04-7

Basic information

• Product Name: 3,5-Difluoropicolinic acid
• Synonyms: 3,5-Difluoropicolinic acid;2-Pyridinecarboxylicacid,3,5-difluoro-(9CI);3,5-Difluoropyridine-2-carboxylic acid;3,5-difluoropyridine-2-carbxylic acid;3,5-Difluoropicolinic acid, 2-Carboxy-3,5-difluoropyridine
• CAS NO: 745784-04-7
• Molecular Formula: C₆H₃F₂NO₂
• Molecular Weight: 159.09
• Product Categories: HALIDE;GLYCINESCAFFOLD;CARBOXYLICACID;Pyridine series;Carboxylic Acids;Pyridines;Carboxylic Acids;Building Blocks;Pyridine;C6;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 745784-04-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 202-204°C
• Boiling Point: 240.6 °C at 760 mmHg
• Flash Point: 99.3 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.65±0.10(Predicted)
• CAS DataBase Reference: 3,5-Difluoropicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoropicolinic acid(745784-04-7)
• EPA Substance Registry System: 3,5-Difluoropicolinic acid(745784-04-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 745784-04-7(Hazardous Substances Data)

Usage

Description

3,5-Difluoropicolinic acid is a chemical compound with the molecular formula C6H3F2NO2, derived from picolinic acid and featuring two fluorine atoms attached to the third and fifth carbon atoms. 3,5-Difluoropicolinic acid is recognized for its role in the synthesis and development of pharmaceuticals and agrochemicals, as well as its utility in research and development for creating new chemical compounds with potential biological activities. The incorporation of fluorine atoms in its structure makes 3,5-Difluoropicolinic acid a valuable asset in drug discovery and chemical biology, as fluorine substitution can significantly influence the physicochemical and pharmacokinetic properties of molecules, potentially enhancing the development of improved drug candidates.

Uses

Used in Pharmaceutical and Agrochemical Industries:
3,5-Difluoropicolinic acid is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of novel compounds with enhanced biological activities.
Used in Research and Development:
In the field of research and development, 3,5-Difluoropicolinic acid serves as a building block for the creation of new chemical compounds, leveraging its unique structure to explore potential applications in biological and medicinal chemistry.
Used in Drug Discovery and Chemical Biology:
3,5-Difluoropicolinic acid is utilized as a valuable tool in drug discovery and chemical biology, where the presence of fluorine atoms can alter the physicochemical properties and pharmacokinetics of molecules, leading to the discovery of improved drug candidates with optimized performance in biological systems.

InChI:InChI=1/C6H3F2NO2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,(H,10,11)

Upstream product

• 298709-29-2 3,5-difluoropyridine-2-carbonitrile 

Downstream Products

• 745784-03-6 3,5-difluoropyridine amide 
• 955885-64-0 methyl 3,5-difluoropyridine-2-carboxylate 
• 1256836-96-0 methyl 3-fluoro-5-hydroxypyridine-2-carboxylate 
• 1374344-60-1 isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate 
• 1105510-20-0 (2R,6S)-4-(6-bromo-2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine 
• 1105510-17-5 (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine 
• 1105511-51-0 (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine 
• 1227511-52-5 3-fluoro-5-methoxypyridine-2-carboxylic acid 

Relevant articles and documents

SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ?-SECRETASE-INHIBITING ACTIVITY

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.