2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde

Base Information

• Chemical Name: 2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde
• CAS No.: 129880-85-9
• Molecular Formula: C14H14 N2 O2 S
• Molecular Weight: 274.34
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40368111
• Wikidata: Q27198053
• ChEMBL ID: CHEMBL1510608
• Mol file: 129880-85-9.mol

Synonyms:129880-85-9;2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde;2-Morpholino-4-phenylthiazole-5-carbaldehyde;2-morpholin-4-yl-4-phenyl-1,3-thiazole-5-carbaldehyde;2-(morpholin-4-yl)-4-phenyl-1,3-thiazole-5-carbaldehyde;5-Thiazolecarboxaldehyde,2-(4-morpholinyl)-4-phenyl-;Oprea1_277525;MLS001005916;SCHEMBL7062983;CHEMBL1510608;DTXSID40368111;CHEBI:115703;HMS2735P08;MFCD02710803;STL191168;AKOS000115376;5-formyl-2-morpholino-4-phenyl-thiazole;SMR000349053;CS-0218456;EN300-01034;AB00619047-02;2-morpholin-4-yl-4-phenylthiazole-5-carbaldehyde;2-(4-morpholinyl)-4-phenyl-5-thiazolecarboxaldehyde;Q27198053;Z56797473

Chemical Property of 2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde

Chemical Property:

• Vapor Pressure: 1.27E-09mmHg at 25°C
• Boiling Point: 486.6°Cat760mmHg
• Flash Point: 248.1°C
• PSA: 70.67000
• Density: 1.291g/cm³
• LogP: 2.52420
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 274.07759887
• Heavy Atom Count: 19
• Complexity: 304

Purity/Quality:

99% ^*data from raw suppliers

2-(morpholin-4-yl)-4-phenyl-1,3-thiazole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC(=C(S2)C=O)C3=CC=CC=C3

Technology Process of 2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde

There total 5 articles about 2-Morpholin-4-yl-4-phenyl-thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H16N2O2S → 2-(morpholin-4-yl)-4-phenylthiazole-5-carbaldehyde (129880-85-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2019.115090

Reference yield:

benzoyl chloride (98-88-4) → 2-(morpholin-4-yl)-4-phenylthiazole-5-carbaldehyde (129880-85-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetonitrile / 3 h / Reflux

1.2: 0.5 h / 20 °C

2.1: TEA / ethanol / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4.1: manganese(IV) oxide / dichloromethane / 1 h / 0 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2019.115090

Reference yield:

N-(morpholinothiocarbonyl)benzamide (40398-30-9) → 2-(morpholin-4-yl)-4-phenylthiazole-5-carbaldehyde (129880-85-9)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / ethanol / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: manganese(IV) oxide / dichloromethane / 1 h / 0 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmc.2019.115090

upstream raw materials:

4-morpholinecarboxaldehyde

2-chloro-4-phenylthiazole

benzoyl chloride

N-(morpholinothiocarbonyl)benzamide

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