Technology Process of (1R,2S)-5,8-dimethoxy-2-(4-methoxybenzyl)-1,2,3,4-tetrahydronaphthalen-1-ol
There total 8 articles about (1R,2S)-5,8-dimethoxy-2-(4-methoxybenzyl)-1,2,3,4-tetrahydronaphthalen-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-5,8-dimethoxy-2-(4-methoxybenzylidene)-3,4-dihydronaphthalen-1(2H)-one;
With
[N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]-ruthenium; cetyltrimethylammonim bromide; copper(II) bis(trifluoromethanesulfonate);
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
sodium formate;
In
water; 1,2-dichloro-ethane;
at 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/acs.joc.0c02981
- Guidance literature:
-
With
[N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]-ruthenium; sodium formate; cetyltrimethylammonim bromide; copper(II) bis(trifluoromethanesulfonate);
In
water; 1,2-dichloro-ethane;
at 20 ℃;
for 72h;
DOI:10.1021/acs.joc.0c02981
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / methanol; water / 24 h / 0 - 20 °C / Reflux
2.1: [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]-ruthenium; cetyltrimethylammonim bromide; copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere
2.2: 72 h / 20 °C / Inert atmosphere
With
hydrogenchloride; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]-ruthenium; cetyltrimethylammonim bromide; copper(II) bis(trifluoromethanesulfonate);
In
methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.0c02981
