N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Base Information

Chemical Name:N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester
CAS No.:857870-30-5
Molecular Formula:C₂₇H₂₂Cl₂IN₃O₅
Molecular Weight:666.299
Hs Code.:

Synonyms:N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

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Chemical Property of N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

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Technology Process of N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

There total 4 articles about N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857870-28-1
4-[(2-amino-5-iodobenzoyl)amino]-N-(2,6-dichlorobenzoyl)-L-phenylalanine isopropyl ester

: 530-62-1
1,1'-carbonyldiimidazole

: 857870-30-5
N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: In DMF (N,N-dimethyl-formamide); at 80 ℃;

Reference yield:

: 401906-14-7
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine

: 857870-30-5
N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / tetrahydrofuran / 120 h / 50 °C

2: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4: N,N-dimethyl-formamide / 20 - 80 °C

With sulfuric acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3percent Pt-S/C; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 857870-36-1
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine isopropyl ester

: 857870-30-5
N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 20 - 80 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3percent Pt-S/C; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;