L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-(1,4-dihydro-6-iodo-1-methyl-2,4-dioxo-3(2H )-quinazolinyl)-, 1-methylethyl ester

Base Information

Chemical Name:L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-(1,4-dihydro-6-iodo-1-methyl-2,4-dioxo-3(2H )-quinazolinyl)-, 1-methylethyl ester
CAS No.:857870-32-7
Molecular Formula:C28H24Cl2IN3O5
Molecular Weight:680.326
Hs Code.:

Synonyms:

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Chemical Property of L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-(1,4-dihydro-6-iodo-1-methyl-2,4-dioxo-3(2H )-quinazolinyl)-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-(1,4-dihydro-6-iodo-1-methyl-2,4-dioxo-3(2H )-quinazolinyl)-, 1-methylethyl ester

There total 5 articles about L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-(1,4-dihydro-6-iodo-1-methyl-2,4-dioxo-3(2H )-quinazolinyl)-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857870-30-5
N-(2,6-dichlorobenzoyl)-4-(6-iodo-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

: 74-88-4
methyl iodide

: 857870-32-7
N-(2,6-dichlorobenzoyl)-4-(6-iodo-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 4h;

Reference yield:

: 401906-14-7
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine

: 857870-32-7
N-(2,6-dichlorobenzoyl)-4-(6-iodo-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / tetrahydrofuran / 120 h / 50 °C

2: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4: N,N-dimethyl-formamide / 20 - 80 °C

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With sulfuric acid; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3percent Pt-S/C; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 857870-36-1
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine isopropyl ester

: 857870-32-7
N-(2,6-dichlorobenzoyl)-4-(6-iodo-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-(2H)-yl)-L-phenylalanine isopropylester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 20 - 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3percent Pt-S/C; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;