C₁₈H₁₀BrClFN₃O₂S

Base Information

Chemical Name:C₁₈H₁₀BrClFN₃O₂S
CAS No.:1089179-02-1
Molecular Formula:C₁₈H₁₀BrClFN₃O₂S
Molecular Weight:466.718
Hs Code.:

C<sub>18</sub>H<sub>10</sub>BrClFN<sub>3</sub>O<sub>2</sub>S

Synonyms:C₁₈H₁₀BrClFN₃O₂S

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Chemical Property of C₁₈H₁₀BrClFN₃O₂S

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Technology Process of C₁₈H₁₀BrClFN₃O₂S

There total 8 articles about C₁₈H₁₀BrClFN₃O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: C₁₈H₁₂BrClFNO₃

: 17356-08-0
thiourea

: 109-94-4
formic acid ethyl ester

: 1089179-02-1
C₁₈H₁₀BrClFN₃O₂S

Guidance literature:: C₁₈H₁₂BrClFNO₃; formic acid ethyl ester; With potassium tert-butylate; In diethyl ether; at 20 ℃; for 18h;

thiourea; In isopropyl alcohol; at 80 ℃; for 4h;

Reference yield:

: 473923-97-6
3-chloro-5-hydroxybenzonitrile

: 1089179-02-1
C₁₈H₁₀BrClFN₃O₂S

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / ISOPROPYLAMIDE / 0.5 h / 50 °C

1.2: 2 h / 125 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / -78 °C

2.2: 2 h / -50 °C

2.3: -78 - 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

5.2: 1.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

6.3: 0.33 h / 160 °C / Microwave irradiation

7.1: potassium tert-butylate / diethyl ether / 18 h / 20 °C

7.2: 4 h / 80 °C

With sodium tetrahydroborate; potassium tert-butylate; isopropylmagnesium chloride; phosphorus tribromide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1007571-63-2
3-(6-bromo-2-fluoro-3-formyl-phenoxy)-5-chloro-benzonitrile

: 1089179-02-1
C₁₈H₁₀BrClFN₃O₂S

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 24 h / 20 °C

2.1: phosphorus tribromide / dichloromethane / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

4.3: 0.33 h / 160 °C / Microwave irradiation

5.1: potassium tert-butylate / diethyl ether / 18 h / 20 °C

5.2: 4 h / 80 °C

With sodium tetrahydroborate; potassium tert-butylate; phosphorus tribromide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;