Technology Process of 7-(5-(2-(diethylamino)ethoxy)pyridin-2-ylamino)-1-isopropyl-3-phenyl-1,6-naphthyridin-2(1H)-one
There total 9 articles about 7-(5-(2-(diethylamino)ethoxy)pyridin-2-ylamino)-1-isopropyl-3-phenyl-1,6-naphthyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos;
In
1,4-dioxane;
at 100 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 16 h / 20 °C
2: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 °C
3: manganese(IV) oxide / dichloromethane / 5 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 100 °C
5: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
With
manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; sodium t-butanolate; lithium diisopropyl amide; XPhos;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium diacetate; potassium acetate; bis(pinacol)diborane / N,N-dimethyl-formamide / 16 h / 100 °C
1.2: 16 h / 20 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C
3.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C
4.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; potassium acetate; palladium diacetate; triphenylphosphine; bis(pinacol)diborane; sodium t-butanolate; XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;