(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

Base Information

Chemical Name:(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol
CAS No.:87060-34-2
Molecular Formula:C₃₅H₆₆O₄Si
Molecular Weight:578.992
Hs Code.:

Synonyms:(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

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Technology Process of (2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

There total 9 articles about (2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 87060-33-1
(2R,3R)-2-Benzyloxy-4-octadecyloxy-butane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 87060-34-2
(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88010-7

Reference yield:

: 34370-91-7,59358-33-7,68354-70-1,70798-12-8,19139-80-1
3-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose

: 87060-34-2
(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / (n-But)4HSO₄,50percent NaOH / 24 h / 70 °C

2: 98 percent / 2percent H₂SO₄ / dioxane / 3 h / 90 °C

3: NaIO₄ / dioxane; H₂O

4: NaBH₄ / ethanol

5: 98 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; sodium periodate; (n-But)4HSO₄,50percent NaOH; sulfuric acid; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88010-7

Reference yield:

: 100-39-0
benzyl bromide

: 87060-34-2
(2R,3R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-octadecyloxy-butan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1: (n-But)4NI,NaH / tetrahydrofuran

2: 0.8 percent H₂SO₄ / methanol / 24 h

3: NaI₄ / dioxane; H₂O

4: NaBH₄ / ethanol

5: 86 percent / (n-But)4HSO₄,50percent NaOH / 24 h / 70 °C

6: 98 percent / 2percent H₂SO₄ / dioxane / 3 h / 90 °C

7: NaIO₄ / dioxane; H₂O

8: NaBH₄ / ethanol

9: 98 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; sodium periodate; (n-But)4HSO₄,50percent NaOH; sulfuric acid; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88010-7