(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

Base Information

Chemical Name:(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one
CAS No.:182058-02-2
Molecular Formula:C₁₇H₂₄N₄O₃Si
Molecular Weight:360.488
Hs Code.:

Synonyms:(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

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Chemical Property of (S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

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Technology Process of (S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

There total 3 articles about (S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 34897-85-3
o-azidobenzoyl chloride

: 130403-91-7
(3S)-3-[tert-butyl(dimethyl)silyl]oxypyrrolidin-2-one

: 182058-02-2
(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; paraffin; 1.) 0 deg C, 15 min, 2.) room temperature, 3 h;
DOI:10.1021/jo9609283

Reference yield:

: 31162-13-7
2-azidobenzoic acid

: 182058-02-2
(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / neat (no solvent) / 2 h / Heating

2: 83 percent / NaH / tetrahydrofuran; paraffin / 1.) 0 deg C, 15 min, 2.) room temperature, 3 h

With thionyl chloride; sodium hydride; In tetrahydrofuran; paraffin;
DOI:10.1021/jo9609283

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 182058-02-2
(S)-1-(2-Azido-benzoyl)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / pyridine; CH₂Cl₂ / Ambient temperature

2: 83 percent / NaH / tetrahydrofuran; paraffin / 1.) 0 deg C, 15 min, 2.) room temperature, 3 h

With sodium hydride; In tetrahydrofuran; pyridine; dichloromethane; paraffin;
DOI:10.1021/jo9609283