1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

Base Information

Chemical Name:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol
CAS No.:153943-16-9
Molecular Formula:C₂₇H₂₂N₂O₃
Molecular Weight:422.483
Hs Code.:

Synonyms:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

Chemical Property:

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Technology Process of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

There total 5 articles about 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 153943-07-8
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

: 153943-16-9
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jo00080a015

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 153943-16-9
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / NaH / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) 0 deg C to room temp., 3 h; 75 deg C, 16 h

2: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

3: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

4: 80 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; vinyl magnesium bromide; sodium hydride; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00080a015

Reference yield:

: 14178-18-8
2-(Benzyloxy)nicotinic acid

: 153943-16-9
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

2: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

3: 80 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; vinyl magnesium bromide; 1,1'-carbonyldiimidazole; In ethanol;
DOI:10.1021/jo00080a015