1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Base Information

Chemical Name:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one
CAS No.:153943-07-8
Molecular Formula:C₂₇H₂₀N₂O₃
Molecular Weight:420.467
Hs Code.:

Synonyms:1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Suppliers and Price of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

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Chemical Property of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Chemical Property:

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Technology Process of 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

There total 4 articles about 1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 153943-07-8
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaH / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) 0 deg C to room temp., 3 h; 75 deg C, 16 h

2: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

3: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

With vinyl magnesium bromide; sodium hydride; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jo00080a015

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 153943-07-8
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaH / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) 0 deg C to room temp., 3 h; 75 deg C, 16 h

2: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

3: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

With vinyl magnesium bromide; sodium hydride; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jo00080a015

Reference yield:

: 14178-18-8
2-(Benzyloxy)nicotinic acid

: 153943-07-8
1-(3-(2-(Benzyloxy)pyridyl))-3-(6-(2-(benzyloxy)pyridyl))-2-propyn-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) carbonyldiimidazole / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, room temp., 24 h

2: 1.) vinylmagnesium bromide / 1.) THF, 0 deg C to room temp., 1 h, 2.) THF, reflux, 4 h

With vinyl magnesium bromide; 1,1'-carbonyldiimidazole;
DOI:10.1021/jo00080a015