methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

Base Information

Chemical Name:methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate
CAS No.:238421-73-3
Molecular Formula:C₂₅H₄₀O₆Si
Molecular Weight:464.674
Hs Code.:

Synonyms:methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

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Chemical Property of methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

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Technology Process of methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

There total 6 articles about methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 238421-72-2
(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

: 238421-73-3
methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

Guidance literature:: In benzene; for 18h; Heating;

Reference yield:

: 238421-40-4
(5S)-4-hydroxy-3-(4-methoxyphenyl)-5-(2-propyl)-2(5H)-furanone

: 238421-73-3
methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Et₃N / tetrahydrofuran / 24 h / 30 °C

2: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

3: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

4: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

5: 89 percent / Pb(OAc)4 / benzene / 0.08 h / 20 °C

6: 94 percent / benzene / 18 h / Heating

With lead(IV) acetate; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: Addition / 2: ketalization / 3: Reduction / 4: silylation / 5: Oxidation / 6: Wittig reaction;

Reference yield:

: 238421-61-9
(3R,5S)-3-(4-methoxyphenyl)-3-(3-oxobutyl)-5-(2-propyl)-2,4(3H,5H)-furadione

: 238421-73-3
methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

2: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

3: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

4: 89 percent / Pb(OAc)4 / benzene / 0.08 h / 20 °C

5: 94 percent / benzene / 18 h / Heating

With lead(IV) acetate; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: ketalization / 2: Reduction / 3: silylation / 4: Oxidation / 5: Wittig reaction;