5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

Base Information

Chemical Name:5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole
CAS No.:258879-00-4
Molecular Formula:C₂₉H₂₆N₄O
Molecular Weight:446.552
Hs Code.:

Synonyms:5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

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Chemical Property of 5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

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Technology Process of 5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

There total 7 articles about 5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 258878-31-8
5-(4-biphenyl)-4-(2-hydroxyphenyl)-3-methyl-1,2,4-triazole

: 258879-00-4
5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm010544r

Reference yield:

: 34288-19-2
N-(2-(benzyloxy)phenyl)acetamide

: 258879-00-4
5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / P₂S₂ / toluene / 2 h / 70 °C

2: 79 percent / K₂CO₃ / acetonitrile / 3 h / 50 °C

3: dimethylformamide / 23 h / 120 °C

4: 3.45 g / H₂ / 10percent Pd/C / dimethylformamide / 19 h / 20 °C / 3040.2 Torr

5: 84 percent / Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; 10percent Pd/C; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm010544r

Reference yield:

: 95-55-6
2-amino-phenol

: 258879-00-4
5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / ethyl acetate / 3 h / 20 °C

2: 86 percent / K₂CO₃ / acetonitrile / 8 h / 70 °C

3: 81 percent / P₂S₂ / toluene / 2 h / 70 °C

4: 79 percent / K₂CO₃ / acetonitrile / 3 h / 50 °C

5: dimethylformamide / 23 h / 120 °C

6: 3.45 g / H₂ / 10percent Pd/C / dimethylformamide / 19 h / 20 °C / 3040.2 Torr

7: 84 percent / Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; 10percent Pd/C; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm010544r