N-(2-(benzyloxy)phenyl)acetamide

Base Information

• Chemical Name: N-(2-(benzyloxy)phenyl)acetamide
• CAS No.: 34288-19-2
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2924299090
• ChEMBL ID: CHEMBL4789456
• DSSTox Substance ID: DTXSID601034579
• Mol file: 34288-19-2.mol

Synonyms:N-(2-(benzyloxy)phenyl)acetamide;34288-19-2;N-[2-(benzyloxy)phenyl]acetamide;N-(2-phenylmethoxyphenyl)acetamide;CHEMBL4789456;SCHEMBL8924076;DTXSID601034579;BDBM50546341;MFCD03090753;AKOS000502480;Acetamide, N-[2-(phenylmethoxy)phenyl]-;CS-0214953;EN300-207125;AN-329/43449863;Z26365442

Chemical Property of N-(2-(benzyloxy)phenyl)acetamide

Chemical Property:

• PSA: 41.82000
• LogP: 3.87350
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

97% ^*data from raw suppliers

N-(2-(benzyloxy)phenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CC=C1OCC2=CC=CC=C2

Technology Process of N-(2-(benzyloxy)phenyl)acetamide

There total 5 articles about N-(2-(benzyloxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

benzyl bromide (100-39-0) + 2-(acetylamino)phenol (614-80-2) → N-(2-(benzyloxy)phenyl)acetamide (34288-19-2)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c02156

Reference yield:

2-amino-phenol (95-55-6) → N-(2-(benzyloxy)phenyl)acetamide (34288-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / ethyl acetate / 3 h / 20 °C

2: 86 percent / K₂CO₃ / acetonitrile / 8 h / 70 °C

With potassium carbonate; In ethyl acetate; acetonitrile;

DOI:10.1021/jm010544r

Reference yield:

o-(benzyloxy)aniline (20012-63-9) + acetyl chloride (75-36-5) → N-(2-(benzyloxy)phenyl)acetamide (34288-19-2)

Guidance literature:

With pyridine;

DOI:10.1016/S0968-0896(02)00009-3

upstream raw materials:

o-(benzyloxy)aniline

acetic anhydride

acetyl chloride

benzyl bromide

Downstream raw materials:

2-benzyloxy-4-nitro-phenylamine

acetic acid-(2-benzyloxy-5-nitro-anilide)

o-(benzyloxy)aniline

2-amino-4-nitrophenyl benzyl ether