N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide)

Base Information

• Chemical Name: N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide)
• CAS No.: 1346686-34-7
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 1346686-34-7.mol

Synonyms:N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide)

Chemical Property of N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide)

There total 6 articles about N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N'-(4,6-bis((trimethylsilyl)ethynyl)-1,3-phenylene)bis(2,2-dimethylpropanamide) (1346686-33-6) → N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide) (1346686-34-7)

Guidance literature:

With methanol; potassium carbonate; In tetrahydrofuran; for 0.25h;

DOI:10.1021/ol202729z

Reference yield: 46.0%

N,N'-(4,6-bis((trimethylsilyl)ethynyl)-1,3-phenylene)bis(2,2-dimethylpropanamide) (1346686-33-6) → N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide) (1346686-34-7) + N,N'-(4-ethynyl-6-((trimethylsilyl)ethynyl)-1,3-phenylene)bis(2,2-dimethylpropanamide) (1582301-41-4)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja500125r

Reference yield:

N,N'-(1,3-phenylene)bis(2,2-dimethylpropanamide) (25116-08-9) → N,N'-(4,6-diethynyl-1,3-phenylene)bis(2,2-dimethylpropanamide) (1346686-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Iodine monochloride / chloroform / 24 h / 60 °C

2: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; diisopropylamine / tetrahydrofuran / 3 h / 20 °C

3: methanol; potassium carbonate / tetrahydrofuran / 0.25 h

With methanol; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; Iodine monochloride; potassium carbonate; diisopropylamine; In tetrahydrofuran; chloroform;

DOI:10.1021/ol202729z

upstream raw materials:

N,N'-(4,6-diiodo-1,3-phenylene)bis(2,2-dimethylpropanamide)

N,N'-(4,6-bis((trimethylsilyl)ethynyl)-1,3-phenylene)bis(2,2-dimethylpropanamide)

N,N'-(1,3-phenylene)bis(2,2-dimethylpropanamide)

pivaloyl chloride

Downstream raw materials:

C₄₀H₅₀N₈O₂

C₄₂H₅₂N₁₀O₄