8-Methoxy-chroman-3-carboxylic acid

Base Information

Chemical Name:8-Methoxy-chroman-3-carboxylic acid
CAS No.:108088-19-3
Molecular Formula:C11H12 O4
Molecular Weight:208.21
Hs Code.:2932999099
European Community (EC) Number:841-085-1
DSSTox Substance ID:DTXSID00390332
ChEMBL ID:CHEMBL1878244
Mol file:108088-19-3.mol

Synonyms:8-Methoxy-chroman-3-carboxylic acid;108088-19-3;8-METHOXYCHROMAN-3-CARBOXYLIC ACID;8-methoxy-3,4-dihydro-2H-chromene-3-carboxylic acid;8-methoxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid;8-Methoxychroman-3-carboxylicacid;MLS000716551;CHEMBL1878244;DTXSID00390332;HMS2654D13;MFCD04114622;AKOS000125389;AKOS016050882;AB18704;AS-42615;SMR000278068;8-METHOXY-3-CHROMANECARBOXYLIC ACID;FT-0677780;EN300-68269;8-methoxy-chroman-3-carboxylic acid, AldrichCPR;A801858;SR-01000325172;SR-01000325172-1;BRD-A43673065-001-07-7;F8889-4896;Z363996242

Suppliers and Price of 8-Methoxy-chroman-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
8-Methoxy-chroman-3-carboxylicAcid
50mg
$ 60.00

Matrix Scientific
8-Methoxy-chroman-3-carboxylic acid
500mg
$ 182.00

J&W Pharmlab
8-Methoxy-chroman-3-carboxylicacid 96%
25g
$ 720.00

Crysdot
8-Methoxychroman-3-carboxylicacid 95+%
5g
$ 307.00

Chemenu
8-Methoxychroman-3-carboxylicacid 95%
5g
$ 290.00

ChemBridge Corporation
8-methoxychromane-3-carboxylicacid 95%
1 g
$ 46.00

American Custom Chemicals Corporation
8-METHOXY-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID 95.00%
2.5G
$ 1147.43

Alichem
8-Methoxy-chroman-3-carboxylicacid
25g
$ 751.41

Alichem
8-Methoxy-chroman-3-carboxylicacid
5g
$ 280.83

AK Scientific
8-Methoxy-chroman-3-carboxylicacid
5g
$ 212.00

Total 12 raw suppliers

Chemical Property of 8-Methoxy-chroman-3-carboxylic acid

Chemical Property:

Vapor Pressure:8.28E-07mmHg at 25°C
Melting Point:171-173 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Refractive Index:1.559
Boiling Point:390.8°C at 760 mmHg
PKA:4.14±0.20(Predicted)
Flash Point:156.6°C
PSA：55.76000
Density:1.273g/cm³
LogP:1.33090
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:208.07355886
Heavy Atom Count:15
Complexity:241

Purity/Quality:

97% ^*data from raw suppliers

8-Methoxy-chroman-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C1OCC(C2)C(=O)O

Technology Process of 8-Methoxy-chroman-3-carboxylic acid

There total 2 articles about 8-Methoxy-chroman-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 57543-59-6
8-methoxy-2H-chromene-3-carboxylic acid

: 108088-19-3
3,4-dihydro-8-methoxy-2H-1-benzopyran-3-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 12h; Ambient temperature;
DOI:10.1248/cpb.35.632

Reference yield:

: 2495-35-4,25036-21-9
benzylacrylate

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 108088-19-3
3,4-dihydro-8-methoxy-2H-1-benzopyran-3-carboxylic acid

Guidance literature:: benzylacrylate; 3-methoxy-2-hydroxybenzaldehyde; With 1,4-diaza-bicyclo[2.2.2]octane; Heating;

With 1% Pd/C; hydrogen;
DOI:10.1016/j.bmcl.2010.01.124

Reference yield: 70.0%

: 108088-19-3
3,4-dihydro-8-methoxy-2H-1-benzopyran-3-carboxylic acid

: 446065-11-8
cyclohexyltrifluoro-λ⁴-borane potassium salt

: cyclohexyl(8-methoxychroman-3-yl)methanone

Guidance literature:: With Ir(dF(CF₃)ppy)2(bpy)PF₆; tetraaqua[4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]nickel(II) chloride; ammonium chloride; dimethyl dicarbonate; In tetrahydrofuran; Isopropyl acetate; at 24 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Irradiation;
DOI:10.1021/acs.orglett.7b01588