(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

Base Information

Chemical Name:(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate
CAS No.:1037287-75-4
Molecular Formula:BF₄*C₁₉H₂₄N₃O
Molecular Weight:397.224
Hs Code.:

Synonyms:(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

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Chemical Property of (5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

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Technology Process of (5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

There total 4 articles about (5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1037287-73-2
(1R,2S,7R,8S)-(+)-1,11,11-trimethyl-3-oxa-6-aza-tricyclo-[6.2.1.0(2,7)]undecan-5-one

: 420-37-1
trimethoxonium tetrafluoroborate

: 100-63-0
phenylhydrazine

: 1037287-75-4
(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

Guidance literature:: (1R,2S,7R,8S)-(+)-1,11,11-trimethyl-3-oxa-6-aza-tricyclo-[6.2.1.0(2,7)]undecan-5-one; trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 24h;

phenylhydrazine; In dichloromethane; at 20 ℃; for 24h;

With orthoformic acid triethyl ester; In chlorobenzene; at 110 ℃; for 72h; Further stages.;
DOI:10.1039/b801004h

Reference yield: 20.0%

: 1037287-73-2
(1R,2S,7R,8S)-(+)-1,11,11-trimethyl-3-oxa-6-aza-tricyclo-[6.2.1.0(2,7)]undecan-5-one

: 122-51-0
orthoformic acid triethyl ester

: 100-63-0
phenylhydrazine

: 1037287-75-4
(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

Guidance literature:: (1R,2S,7R,8S)-(+)-1,11,11-trimethyl-3-oxa-6-aza-tricyclo-[6.2.1.0(2,7)]undecan-5-one; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 16h;

phenylhydrazine; In dichloromethane; for 24h;

orthoformic acid triethyl ester; In chlorobenzene; at 125 ℃; for 12h;
DOI:10.1016/j.tetasy.2011.04.001

Reference yield:

: C₁₂H₂₀ClNO₂

: 1037287-75-4
(5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 0 - 20 °C

2.1: trimethoxonium tetrafluoroborate / dichloromethane / 16 h / 20 °C

2.2: 24 h

2.3: 12 h / 125 °C

With potassium tert-butylate; trimethoxonium tetrafluoroborate; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.tetasy.2011.04.001