6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Base Information

• Chemical Name: 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine
• CAS No.: 251930-63-9
• Molecular Formula: C₂₁H₁₇F₂N₃O₇
• Molecular Weight: 461.379

Synonyms:6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Chemical Property of 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Chemical Property:

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Technology Process of 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

There total 4 articles about 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

4-Nitrophenyl chloroformate (7693-46-1) + 4-(2,4-difluoro-phenyl)-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester (251930-55-9) → 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-63-9)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm990200p

Reference yield:

2,4-difluorobenzaldehyde (1550-35-2) → 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine; AcOH / benzene / 8 h / Heating

2: NaHCO₃ / dimethylformamide / 16 h / 70 °C

3: 14 percent / DMAP / CH₂Cl₂ / 12 h / 20 °C

With piperidine; dmap; sodium hydrogencarbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; benzene; 1: Condensation / 2: Condensation / 3: Carboxylation;

DOI:10.1021/jm990200p

Reference yield:

acetoacetic acid methyl ester (105-45-3) → 6-(2,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine; AcOH / benzene / 8 h / Heating

2: NaHCO₃ / dimethylformamide / 16 h / 70 °C

3: 14 percent / DMAP / CH₂Cl₂ / 12 h / 20 °C

With piperidine; dmap; sodium hydrogencarbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; benzene; 1: Condensation / 2: Condensation / 3: Carboxylation;

DOI:10.1021/jm990200p

upstream raw materials:

4-Nitrophenyl chloroformate

4-(2,4-difluoro-phenyl)-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

2,4-difluorobenzaldehyde

acetoacetic acid methyl ester

Downstream raw materials:

6-(2,4-difluoro-phenyl)-2-methoxy-1-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-4-methyl-1,6-dihydro-pyrimidine-5-carboxylic acid methyl ester

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