1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

Base Information

Chemical Name:1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate
CAS No.:943025-90-9
Molecular Formula:C₁₆H₂₁F₂N₃O₄
Molecular Weight:357.357
Hs Code.:

Synonyms:1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

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Chemical Property of 1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

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Technology Process of 1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

There total 1 articles about 1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 943025-90-9
1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 4 h / Heating / reflux

1.2: pH 2 / Acidic conditions

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 100 °C

3.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / dioxane,1,4 / 100 °C

4.1: sodium hydrogencarbonate; Selectfluor / water; acetonitrile / 0.58 h / 0 - 20 °C

4.2: 0.17 h

5.1: toluene / 2 h / 40 °C

With diphenyl phosphoryl azide; sodium hydrogencarbonate; Selectfluor; triethylamine; cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In methanol; dioxane,1,4; water; toluene; acetonitrile;

Reference yield:

: 943025-90-9
1,1-dimethylethyl [2-[3-(dimethylamino)-2-fluoroacryloyl]-5-fluoro-6-(methyloxy)-3-pyridinyl] carbamate

: 943025-91-0
8-bromo-3,7-difluoro-2-(methyloxy)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

1.2: Alkaline conditions

2.1: phosphorus tribromide / N,N-dimethyl-formamide / 1.5 h

2.2: Alkaline conditions

With phosphorus tribromide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;