ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Base Information

Chemical Name:ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate
CAS No.:1301660-75-2
Molecular Formula:C₃₂H₃₀F₇N₃O₄
Molecular Weight:653.597
Hs Code.:

ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Synonyms:ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Suppliers and Price of ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

There total 7 articles about ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1301660-74-1
diethyl 2-{[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]carbonyl}butanedioate

: 1301660-75-2
ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Guidance literature:: diethyl 2-{[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]carbonyl}butanedioate; With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; Reflux;

With water; sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-75-2
ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / Reflux

4.1: potassium tert-butylate / 4 h / 75 °C

5.1: potassium carbonate; sodium iodide / 1,2-dimethoxyethane; acetone / Reflux

6.1: sodium cyanoborohydride; ammonium acetate / methanol / 20 °C / Reflux

With hydrogenchloride; osmium(VIII) oxide; potassium tert-butylate; ammonium acetate; water; sodium cyanoborohydride; sodium carbonate; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetone; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-71-8
methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

: 1301660-75-2
ethyl 2-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)-amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / 4 h / 75 °C

2: potassium carbonate; sodium iodide / 1,2-dimethoxyethane; acetone / Reflux

3: sodium cyanoborohydride; ammonium acetate / methanol / 20 °C / Reflux

With potassium tert-butylate; ammonium acetate; sodium cyanoborohydride; potassium carbonate; sodium iodide; In methanol; 1,2-dimethoxyethane; acetone;