N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide

Base Information

• Chemical Name: N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide
• CAS No.: 170918-35-1
• Molecular Formula: C₁₂H₁₄Cl₃NO₂
• Molecular Weight: 310.608
• Mol file: 170918-35-1.mol

Synonyms:N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide

Chemical Property of N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide

There total 2 articles about N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(R)-1-amino-2-methyl-1-phenyl-propan-2-ol (110480-87-0) + trifluoroacetyl chloride (76-02-8) → N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide (170918-35-1)

Guidance literature:

With pyridine; 1) 0 deg C, 10 min, 2) room temperature, overnight;

DOI:10.1016/S0040-4020(98)01145-4

Reference yield:

D-phenylglycine methyl ester hydrochloride (19883-41-1,13226-98-7) → N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide (170918-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / diethyl ether / 3 h

2: 65 percent / pyridine / 1) 0 deg C, 10 min, 2) room temperature, overnight

With pyridine; In diethyl ether;

DOI:10.1016/S0040-4020(98)01145-4

Reference yield: 92.0%

N-<(1R)-2-hydroxy-2-methyl-1-phenylpropyl>-2,2,2-trichloroethanamide (170918-35-1) → (R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone (170918-42-0)

Guidance literature:

With potassium carbonate; In ethanol; for 0.5h; Heating;

DOI:10.1016/S0040-4020(98)01145-4

upstream raw materials:

(R)-1-amino-2-methyl-1-phenyl-propan-2-ol

trifluoroacetyl chloride

D-phenylglycine methyl ester hydrochloride

Downstream raw materials:

(R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone

(4R)-3-<3'-phenyl-2'(E)-propenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one