7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

Base Information

Chemical Name:7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile
CAS No.:400754-74-7
Molecular Formula:C₂₀H₂₁ClN₄O
Molecular Weight:368.866
Hs Code.:

Synonyms:7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

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Chemical Property of 7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

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Technology Process of 7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

There total 1 articles about 7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 372090-70-5
7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-[2,7]-naphthyridine-4-carbonitrile

: 400754-74-7
7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2010.03.065

Reference yield: 84.0%

: 400754-74-7
7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 1-amino-7-benzyl-5-(morpholin-4-yl)-6,7,8,9-tetrahydrothieno[2,3-c][2,7]naphthyridine-2-carboxylate

Guidance literature:: With sodium ethanolate; for 5h; Reflux;
DOI:10.1134/S1070428018060155

Reference yield:

: 400754-74-7
7-benzyl-3-chloro-1-(morpholin-4-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

: 9-benzyl-11-(morpholin-4-yl)-7,8,9,10-tetrahydro[1,2,4]triazolo[1″,5″:1′,6′]pyrimido[4′,5′:4,5]thieno[2,3-c][2,7]naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / 5 h / Reflux

2: 5 h / Reflux

3: trichlorophosphate; pyridine / 4 h / Reflux

4: hydrazine / ethanol / 5 h / Reflux

5: 25 h / Reflux

With pyridine; sodium ethanolate; hydrazine; trichlorophosphate; In ethanol;
DOI:10.1134/S1070428018060155