7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

Base Information

• Chemical Name: 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile
• CAS No.: 372090-70-5
• Molecular Formula: C16H13Cl2N3
• Molecular Weight: 318.205
• Mol file: 372090-70-5.mol

Synonyms:7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

Chemical Property of 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

Chemical Property:

• Melting Point: 220 - 223 °C
• PSA: 39.92000
• LogP: 3.75628

Purity/Quality:

99% ^*data from raw suppliers

7-BENZYL-1,3-DICHLORO-6,8-DIHYDRO-5H-2,7-NAPHTHYRIDINE-4-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

There total 6 articles about 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

7-benzyl-1,3-dioxo-1,2,3,4,5,6,7,8-octahydro-[2,7]-naphthyridine-4-carbonitrile (1228692-26-9) → 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-[2,7]-naphthyridine-4-carbonitrile (372090-70-5)

Guidance literature:

With trichlorophosphate; at 180 ℃; for 4h; Sealed tube;

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-[2,7]-naphthyridine-4-carbonitrile (372090-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 4 h / Reflux

2: trichlorophosphate / 4 h / 180 °C / Sealed tube

With potassium hydroxide; trichlorophosphate; In methanol;

Reference yield:

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 7-benzyl-1,3-dichloro-5,6,7,8-tetrahydro-[2,7]-naphthyridine-4-carbonitrile (372090-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane / 1 h

2: potassium hydroxide / methanol / 4 h / Reflux

3: trichlorophosphate / 4 h / 180 °C / Sealed tube

With sodium hydrogencarbonate; potassium hydroxide; trichlorophosphate; In methanol; dichloromethane;

upstream raw materials:

7-benzyl-1,3-dioxo-1,2,3,4,5,6,7,8-octahydro-[2,7]-naphthyridine-4-carbonitrile

C₉H₁₄O₃NC₆H₅

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

N,N-bis(2-ethoxycarbonylethyl)benzylamine

Downstream raw materials:

C₂₁H₂₂ClFN₄

C₂₂H₂₅ClN₄

C₁₈H₁₉ClN₄

C₁₉H₂₁ClN₄

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